Day 1 – Wednesday, 8 October 2014 

13:45 – 14:00 Welcome –  Pre-Conference
Workshop Chair : B. Boulanger, Arlenda, Belgium
14:00 – 17:30 J. Peterson, GSK, USABayesian Applications to Quality-by-Design and Assay Development J. 
19:00 Drink at the Town Hall

Day 2 – Thursday, 9 October 2014

08:15 – 08:30 Welcome – Main Conference
H. Geys, Janssen Pharma,  Belgium
Session 1 Chair : O. Thas,  Ghent University, Belgium

Translational Research

08:30 – 09:15 W. Van Criekinge,  Ghent University, Belgium

Translational epigenomics 

Contributed papers
09:15 – 09:35 K. Gore, Pfizer, UK

Helping to Drive the Robustness of Preclinical Research

09:35 – 09:55 M. Bergquist, GSK, USA

Quantifying Success? Metrics for Non-Clinical Statisticians

09:55 – 10:15 G. Chen, Merck, Netherlands

Bayesian tolerance interval

 10:15 – 10:45 Coffee Break & Poster Session
Session 2 Chair : Pierre Lebrun, Arlenda, Belgium

Bioassays Chair

10:45 – 11:30 C. Tan,  Pfizer, USA

A Step in the Right Direction? the development of USP Chapter <1210>

Contributed papers
11:30 – 11:50 P. Sondag, B. Boulanger, E. Rozet, R. Rousseau, Arlenda, Belgium

Comparison of methodologies to assess the parallelism between two four parameters logistic curves

11:50 – 12:10 J.-F. Michiels, T. Scherder, B. Boulanger, P. Lebrun, A. Jullion, Arlenda, Belgium

A Bayesian framework for conducting effective bridging between references under uncertainty

12:10 – 12:30 A. Baclin, M-P. Malice, G. de Lannoy, M. Key Prato, GSK, Belgium

Control Chart to Monitor Quantitative Assay Consistency

12:30 – 13:45 Lunch & Poster Session
Session 3 Chair : B. Boulanger, Arlenda, Belgium

Chemical Manufacturing & Control Bioassays

13:45 – 14:30 H. Yang, MedImmune, USA

Using statistical  innovation to impact regulatory thinking

Contributed papers
14:30 – 14:50 P. C. Ijzerman-Boon, E. R. van den Heuvel, Merck, Netherlands

Validation of qualitative microbiological test methods

14:50 – 15:10 E. Talens, Merck, Netherlands

Stability of reference standards

15:10 – 15:30 T. Mzolo, G. Goris, A. Di Bucchianico, E. van den Heuvel, University Medical Center Groningen, Netherlands

An Evaluation of Several Statistical Methods for Monitoring the Bioactivity of an In-house Reference Standard

15:30 – 15:50 A. Baclin, C. Bievelet, G. de Lannoy, M. Key-Prato,  M.-P. Malice, GSK, Belgium

A statistical method to demonstrate dilutional linearity for immunoassays

15:50 – 16:20 Coffee Break & Poster Session
Session 4 Chair : Z. Shkedy, Hasselt University

QSTAR- an integrated analysis of biological, chemical and gene expression data in drug discovery

16:20 – 17:05 H. Goehlmann, Janssen Pharma,  Belgium

ADA-Cutpoint estimation – using R: assumptions, solutions, problems

Contributed papers
17:05 – 17:25 F. Mattiello, O. Thas, Ghent University, Belgium

Two Explorative Data Analysis Methods for Discovering Connections Between Three Data Sources, with Applications in Early Drug Development

17:25 – 17:45 N. J. Perualila, Hasselt University, Belgium

Rationalizing CMap Gene Expression Readouts via Target Prediction

17:45 – 18:05 M. Otava, Hasselt University, Belgium

Regression with Enriched random forest

20:00 Conference Dinner at brewery Halve Maan

Day 3 – Friday, 10 October 2014


Session 5 Chair : L. Bijnens, Janssen Pharma,  Belgium

Visualisation techniques 

08:30 – 09:00 D. Smeets, Icometrix, Leuven, Belgium

Volumetric images as a representation of clinical data 

09:00 – 09:30 R. Verbeeck, Janssen Pharma,  Belgium

The best of both worlds: guided analytics in the hands of the SME

09:30- 10:00 T. Verbeke, OpenAnalytics, Belgium

Nonclinical Statistics Computing: The Big Picture

 10:00- 10:30 Coffee Break & Poster Session
Session 6 Chair : G. Verbeke,  iBiostat,Omics
10:30 – 11:15 J. Goeman, Leiden University, Netherlands

Flexible multiple testing for drug screening

Contributed papers
 11:15 – 11:35 B. Verbist, K. Thys, J. Reumers, J. Aerssens, L. Bijnens, L. Clement, O. Thas, Janssen Pharma,  Belgium

Statistical methods for improved variant calling of massively parallel sequencing data within virology applications

Session 7 Chair : L. A. Hothorn, Leibniz University Hannover


11:35 – 12:20 J. Fox, USEPA-ORD-NCEA-W, USA

Test for Significant Toxicity: Time for Changes in the Analysis of Toxicity Test Data

Contributed papers
12:20 – 12:40 L. A. Hothorn, Leibniz University Hannover

ADA-Cutpoint estimation – using R: assumptions, solutions, problems

12:40 – 14:00 Lunch & Poster Session
Session 8 Chair : T. Jacobs, Janssen Pharma,  Belgium


14:00 – 14:45 T. Jaki,  Lancaster University, UK

Statistical approaches for Anti-Drug-Antibody (ADA) identification

Contributed papers
14:45 – 15:05 J. Bright, AstraZeneca, UK

Reduce & Repeat – a way of obtaining more precise XC50s using fewer wells (in vitro) and fewer animals (in vivo)

15:05 – 15:25 S. Janssen, J. Talpos, T. Jacobs, L. Fellini, T. Steckler, Janssen Pharma,  Belgium

Statistical Aspects for the Quantification of Learning Behaviour

15:25 – 15:45 E. Rozet, L. Natalis, B. Matthee, J. Swildens, T. Ritsema, W. Beumer, B. Boulanger, Arlenda, Belgium

Piecewise nonlinear mixed-effects model for modelling Nasal Potential Difference (NPD)


15:45 – 16:05 L. Muchene, M. Otava, Z. Shkedy, T. Jacobs, Hasselt University, Belgium

Determination of the minimum effective dose for correlated dose-response data using Bayesian variable selection (BVS) models

16:05 – 16:25  L. Bijnens, Janssen Pharma,  Belgium

Closing and Concluding Remark

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