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For further details, please contact the organizing team at : info@ncs-conference.org.
You can download the final program in pdf format by clicking on this link.
Scientific Program + Slides
| Monday, September 24, 2012 | |
| 12:00 13:30 |
Registration |
| 13:30 17:00 |
Tutorial: Bayesian Statistics in the NonClinical AreaBruno Boulanger and Pierre Lebrun (material together with Emmanuel Lesaffre) |
| 17:00 19:00 |
Establishment of European Working Group Statistical approaches for Anti-DrugAntibody (ADA) identificationLudwig Hothorn |
| 19:00 21:00 |
Poster Session & Welcome Reception |
| Variability and transfer of analytical methodsMisbah Ahmed |
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| Mixed effect modeling for the identification of pharmacodynamic markers for cancer treatment in a multi-technology approachSabine Bader, C.-H. Ooi, B. Bossenmaier, T. Friess, M.Thomas |
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| Discussion Forum: European working groups in non-clinical statisticsCatherine Hessler |
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| Tuesday, September 25, 2012 | |
| 08:45 09:00 |
WelcomeRichardus Vonk |
| 09:00 10:30 |
Session: Dose ResponseChristian Ritz |
| State of the art in dose-response modellingJens Streibig, Christian Ritz | |
| Dose-response curves in industrial biotechnologyThomas Agersten Poulsen |
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| Automating non-clinical statistics using the R Service Bus. The case of dose response modelingTobias Verbeke |
|
| 10:30 11:00 |
Break |
| 11:00 12:30 |
Session BioassaysEmmanuel Pham |
| An evaluation of methods for determining confirmatory cut-points in enzyme-linked immunosorbent assays (ELISA)Thomas Jaki |
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| Assessing the performance of statistical methods for estimating a common relative potency in bioassaysThembile Mzolo, Edwin van den Heuvel, Marga Hendricks |
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| Comparison of Hemacytometer and HiRes cell counters used in potency assaysPriya Kulkarni, Bill Forrest |
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| Which method to estimate Kd and Ki in fluorescence polarization?Dorothée Tamarelle, Armel Salangros |
|
| 12:30 14:00 |
Lunch Break |
| 14:00 15:30 |
Session Bayesian ApproachesBruno Boulanger |
| Use of a 3 steps bayesian approach for the Behrens-Fisher problem in pre-clinical experimentsKarine Florin, Jean Michel Marin, Antoine Barbieri, Marouane Seffal |
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| Bayesian approach to risk assessment for dissolution testing of a marketed drug productCoppenolle Hans, Altan Stan, Chen Juan, Manola Areti, Shen Yan, Shoung Jyh-Ming |
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| Bayesian analysis of analyte dataJohn Whittaker, Linda Warnock |
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| A Design Space to guarantee the long-term stability of a new formulation given production constraints: a Bayesian perspective.Bruno Boulanger, Pierre Lebrun |
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| A Bayesian model for filling of a product to reduce risk of being OOS in presence of uncertainty.Bruno Boulanger, Pierre Lebrun |
|
| 15:30 16:00 |
Break |
| 16:00 18:00 |
Session QSTARLuc Bijnens |
| Quantitative Structure Transcriptional Activity Relationship (QSTAR)Luc Bijnens, Willem Talloen |
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| Development of predictive models and feature selection using LASSO and elastic netPushpike Thilakarathne, Martion Otava, Nolen Joy Perualila, Tatsiana Khamiakova, Adetayo Kasim, Ziv Shkedy |
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| Analoging in large databases with structural fingerprint featuresMartin Heusel, Andreas Mayr, Günter Klambauer, Andreas Mitterecker, Ulrich Bodenhofer, Djork-Arné Clevert, Sepp Hochreiter |
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| Integrated analysis of microarray data, biological data and chemical data in drug developmentNolen Joy Perualila, Pushpike Thilakarathne, Martion Otava, Tatsiana Khamiakova, Adetayo Kasim, Ziv Shkedy |
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| Biclustering in drug designDjork-Arné Clevert, Günter Klambauer, Andreas Mayr, Andreas Mitterecker, Ulrich Bodenhofer, Martin Heusel, Sepp Hochreiter |
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| Integrated statistical analysis of three data sources for the detection of chemical fingerprint features that are simultaneously associated with bio-assay and transcriptomics data.Alain Visscher, Federico Mattiello, Olivier Thas |
|
| 18:00 22:00 |
Social Event |
| Wednesday, September 26, 2012 | |
| 08:30 09:00 |
Session ManufacturingBruno Boulanger |
| The use of multiple linear regression to find acceptable ranges for manufacturing materialsMike Aylott |
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| Practical applications of statistical process controlKatharina Schiffl |
|
| 09:00 10:30 |
Session ToxicologyLudwig Hothorn |
| Identification of the LOAEL by a model selection procedureLudwig Hothorn, Kuiper, RM, Gerhard, D |
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| Evaluation of statistical methods to construct confidence intervals for the lowest observed effect concentrationXiaoqi Jiang |
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| A novel method to estimate the minimum effective dose for monotone and nonmonotone dose-response relationshipsMartin Wolfsegger |
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| Normalizing to control measurements in dose-response studies: What is the effect on parameter estimates?Annette Kopp-Schneider, Xiaoqi Jiang, Oriana Ponta, Sven Stanzel, Alexius Freyberger, Marc Weimer |
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| Statistical planning and analysis of the HETMN Assay for genotoxicity testingRalph Pirow, Dagmar Fieblinger, Manfred Liebsch, Albrecht Poth, Kerstin Reisinger, Thorsten Wolf, Daniel Gerhard, Ludwig Hothorn |
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| Stochastic models for brain aggregate cell cultures: Quantitative description of neurotoxicityMaria Renner, Annette Kopp-Schneider |
|
| 10:30 11:00 |
Break |
| 11:00 12:30 |
Session Animal to Human TranslationKatja Remlinger |
| Trends in translational sciences: Role of industrial-academic collaborationKhusru Asadullah |
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| Difficulties in Translation from Animal to Man – Some Examples from Neuroscience ResearchDavid Willé |
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| Translation of Pre-Clinical Pharmocokinetic Parameters in the Determination of Dosing in First Time in Human StudiesAlun Bedding |
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| Panel / Audience DiscussionKatja Remlinger | |
| 12:30 13:30 |
Break |
| 13:30 15:30 |
Session VariousRichardus Vonk |
| Estimation of in-vitro dose response curves in the presence of drug resistant viral mutationsDoreen Abainenamar, T. Jacobs, H. Ceulemans, O. Lenz, G. Molenberghs, T. Verbinnen. |
|
| Detecting pharmacodynamic drug-drug interactions – a pharmacometric success storyTom Jacobs, C. Mackie, W. Talloen, T. Steckler, A. Megens |
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| Quantitative assessment of drug interactions by linear mixed effects modelingSven Stanzel, Helene Bayer, Annette Kopp-Schneider |
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| Normal ranges determination with quantile regressionLuc Esserméant |
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| Logistic regression re-modelledTina Müller, Hannes Friedrich Ulbrich |
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| Quasi-species identification with model based clusteringBie Verbist , Koen Van der Borght, Yves Wetzels , Kim Thys, Joke Reumers, Tobias Verbeke, Willem Talloen, Joris Meys, Carl Van Hove, Jeroen Aerssens, Luc Bijnens, Olivier Thas |
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| Biophysical rationale and quantitative benefits of using linear mixed effect models to summarize transitions of peptides to protein abundances in SRMJens Lamerz, Paul Cutler, Anton Belousov, G. Duchateau-Nguyen |
|
| 15:30 15:45 |
CloseRichardus Vonk |