Official Program

DAY 1: 19 October 2022

8:30–9:00
Registration and Welcome
9:00–9:45

Prof. Dr Stijn Vansteelandt

Ugent

Inferring causal pathways from data

9:45–10:05

Wim Van der Elst

Janssen

Causal-inference based methods to identify predictors of treatment success in a personalized medicine setting

10:05–10:25
Mona Emampour
U. Technology
Machine Learning Approaches for Monitoring Processes with Multivariate Count Data
10:25–10:45

Roel Straetemans 

Janssen

A case study on how mechanistic models can help in choosing the best summary measure of efficacy for statistical analysis.

10:45–11:05
Libiger Ondrej
Janssen

Effects of publication bias and hidden multiplicity on reproducibility in biomedical discovery research

11:05–11:25
Coffee Break
11:25–11:45
Bruno Boulanger
PharmaLex

Bayesian Adaptive Design for optimal irradiation dose in mice

11:45–12:05

Clément Laloux and Bruno Boulanger

PharmaLex

Improving reproducibility of pre-clinical studies: lessons learned from bioassays guidelines, DoE theory and Bayesian statistics.

12:05–12:25
G. Duchateau-Nguyen

Roche

Virtual control groups in animal toxicology studies

12:25–12:40
My talk in 3 minutes

Cedric Taverne

GSK

Biological assays linearity demonstration by dose-proportionality model using an equivalence framework with links to clinical outcomes

Mohammad Mehrian

GSK

Longitudinal analysis of omics data using machine learning: evaluation of methodologies to predict the frequency of COPD exacerbations

Tina Lang

Bayer

Project Statistician in Pharmaceutical Research

12:40–14:00
Lunch
14:00–14:45

Prof. Dr Olivier Thas

UHasselt

Statistical detection of synergy: New methods and a comparative study

14:45-15:05

Fanny Windenberger

Sanofi

Exploration of a new method and a new tool for the characterization of in vitro combinations of two compounds for screening purpose in oncology

15:05 - 15:25

Nicholas Hein

Janssen

Evaluation of combination therapies using temporal data

15:25 - 15:45
Coffee Break
15:45–16:30

Dr Stan Altan

Janssen

P-value applications in Nonclinical Pharmaceutical Applications – Time to reconsider

16:30–16:50

Bernard G Francq

GSK

P-value, s-value, b-value, d-value,… What else? The probability of being out of specification!

16:50–17:10
Eric Rozet
PharmaLex
A Bayesian perspective of ICH-Q2 and Q14: how to connect the dots from development to routine.
17:10 - 17:30
Coffee Break
17:30 - 17:50

Yannick Van Haelst

Sanofi

A Bayesian journey to accelerated stability kinetics for faster elucidation of the stability trend in Biologics

Dinner at The Hergé Museum with a presentation by Dr Luc BIJNENS

Appeal to statisticians for a sustainable future.

DAY 2: 20 October 2022

8:30–9:00

Registration

9:00–9:45
Dan Lin
GSK
ScRNA Seq Technology for Vaccine Development: Multi-Omics Analysis for Discovery of Antigen Specificity.
9:45–10:05
Olajumoke Evangelina Owokotomo

Uhasselt

A new (high dimensional) surrogacy measure based on Bayesian Variable Selection Approach: An application to Microbiome experiment

10:05–10:25
Thi Huyen NGUYEN

Uhasselt

Biomarkers detection in Microbiome experiments using Structural equation modelling

10:25–10:45
Lira Pi
Pharmalex

Computational inference tuned with wet-bench results yields a model of the transcriptional regulatory network governing zebrafish periderm differentiation

10:45–10:55
My talk in 3 minutes

Clément Laloux

PharmaLex

Expression of cluster of differentiation (CD) markers in Mesenchymal Stem Cells (MSCs): specific modeling of the data to understand the impact of different factors on markers.

Piotr Prostko

Uhasselt

A statistical framework for joint pre-processing and deconvolution of solid-state NMR mixture spectra

10:55–11:25
Coffee Break
11:25–11:45
Martin Otava
Janssen

Employing random effects in variance components modelling

11:45–12:05
Vahid Nassiri
Open Analytics

A fully in Silico framework to predict Drug-induced liver injury in early stage of drug development

12:05–12:25
Thomas de Marchin
PharmaLex

A new innovative approach to optimize the biosimilar cell-clone selection using high-throughput methods.

12:25–12:45

Alemu Assefa

Janssen
Visualization and quantification of polyfunctionality of T-cells at single cell level
12:45–14:00
Lunch
14:00–14:20

Lin Li

PharmaLex

Current trends and opportunities in Computational Biology

14:20-14:40
Davit Sargsyan and Jocelyn Sendecki
Janssen

Automated Spot Counting and Modeling to Estimate Microbial Concentration in Serial Dilution Experiments

14:40-15:00

Els Pattyn

Sanofi

Development of an adaptable yet fully automated end-user tool that allows a harmonized and regulatory compliant calculation and evaluation of immunogenicity cut-points.

15:00-15:20
Andrea Callegaro

GSK

Prediction of human results based on trials from rat models in the field of vaccines

15:20-15:40
Coffee Break
15:40-16:25

Dr Steven Walfish

USP

Statistics at USPharmacopeia

16:25–16:45
My talk in 3 minutes
Jocelyn Sendecki
Janssen

An interactive Shiny application for using biomarker changes in early decision-making in psoriasis

Leonard Maaya
Janssen

Simulating the drug substance to drug product conversion process in vaccine manufacturing

Stephen Karanja

Janssen
Statistical and scientific considerations in application of two-phase stability model for vaccine shelf-life estimation
Birgit Niederhaus

Sanofi

Evaluation of statistical approaches for comparability and similarity studies

16:45 - 17:05

Yimer Kifle Wasihun

Janssen

Leveraging historical data in process validation

17:05 - 17:25
Chellafe Ensoy-Musoro
Janssen

Application of beta regression response surface model for multidimensional design space construction

17:25 - 17:45

Laurent Natalis

PharmaLex

Setting specifications, or when statisticians can play the Good, the Bad, or the Ugly…

DAY 3: 21 October 2022

8:45–9:30
Dr José Nunez Ares
KULeuven

Advances in Orthogonal Minimally Aliased Response Surface (OMARS) Designs: mixed-level, blocked, and Strong OMARS Design​s

9:30–9:50
Juliane Siebourg-Polster

Roche

Designit: a flexible engine to generate experiment layouts

9:50–10:10

Matthias Brückner

Janssen

Optimal design of experiments using amortized Bayesian inference

10:10–10:30

Arno Strouwen

Janssen

Model based experimental design for accelerated small molecule stability studies

10:30–10:45
My talk in 3 minutes

Francisca Galindo Garre

Janssen
Application of non-linear model to SPLIT-PLOT study DESIGN

Christian Schmid

Roche

Improving production capacity and asset utilization of a biologics drug product line through simulation

Francisca Galindo Garre

Janssen
A Bayesian approach to a simple adjustment for curvature in a vaccine stability study
10:45–11:10
Coffee Break
11:10–11:30

Joris Chau

Open Analytics

A generative modeling approach for trend outlier detection during reaction process transfer

11:30–11:50
Jean-François Michiels
PharmaLex

Process characterization: Correlation structure between two (or more) Critical Quality Attributes when there are multiple measurements per condition

11:50–12:10
Thomas Weißschuh
Boehringer Ingelheim

Equivalence of Dissolution Profiles: Summary of statistical follow-up activities of the M-CERSI workshop 2019

12:10–12:30

Jens Lamerz

Hoffman – La Roche

An update on Roche’s experience with the Impact Ratio, year six: Assessing practical significance of process parameters in small molecule technical development

12:30–12:50

Caroline Leveder

Sanofi

Justification of Small-Scale Models: An Industry Perspective

12:50-13:00
Closing remarks and end of conference

The Adolphe Quetelet Society is delighted to invite you to an exclusive Social Dinner on Wednesday 19th October – 08:00pm

The Hergé Museum
Rue du Labrador, 26 – B-1348 Louvain-la-Neuve

The dinner will be an opportunity to network informally with your colleagues.